Terfenadine
Indications
Terfenadine is used for:
Allergic conditions.
Adult Dose
Oral
Adult: 60-120 mg/day in the morning or
60 mg twice daily.
Max: 120 mg/day.
Child Dose
Oral
Child >12 yr and >50 kg: 60-120 mg/day in the morning or
60 mg twice daily.
Max: 120 mg/day.
Renal Dose
Administration
Contra Indications
Porphyria.
Precautions
Child and elderly. Avoid in patients with cardiac or significant hepatic disease, electrolyte imbalance, or known or suspected prolongation of the QT interval. Lactation, pregnancy.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Terfenadine :
Anxiety, palpitations, insomnia, mild GI distubances, erythema multiforme and galactorrhoea.
Potentially Fatal: Ventricular arrhythmias including torsades de pointes. Palpitations, dizziness, syncope or convulsions may indicate arrhythmias. Hepatitis.
Mechanism of Action
Terfenadine, a piperidine derivative, is a non-sedating H1 receptor antagonist antihistamine.