Testosterone Decanoate + Testosterone Isocaproate + Testosterone Phenyl propionate + Testosterone Propionate
Indications
Testosterone Decanoate + Testosterone Isocaproate + Testosterone Phenyl propionate + Testosterone Propionate is used for:
Testosterone replacement therapy
Adult Dose
Intramuscular
Male hypogonadism
Adult: By deep IM injection 1 ml usually 1 to 4 weeks.
Dosage is based on your medical condition, testosterone blood levels, and response to treatment.
Child Dose
Renal Dose
Administration
Contra Indications
Hypercalcaemia or hypercalciuria, males with breast or prostate carcinoma. Pregnancy and lactation.
Precautions
Cardiovascular disorders, skeletal metastases, renal or hepatic impairment, epilepsy, migraine, diabetes or other conditions which may be aggravated by fluid retention, eg heart failure. Elderly, prepubertal boys. Monitor signs of virilization (females) and development of priapism or excessive sexual stimulation (males). Periodic haemoglobin, lipid determinations and rectal prostate examination.
Pregnancy-Lactation
Interactions
Enhance activities of ciclosporine, antidiabetics, thyroxine, anticoagulants. Long term use of testosterone may cause resistance to effects of neuromuscular blockers. Enhance fluid retention from corticosteroids.
Adverse Effects
Side effects of Testosterone Decanoate + Testosterone Isocaproate + Testosterone Phenyl propionate + Testosterone Propionate :
Fluid and electrolyte retention; increased vascularity of the skin; hypercalcaemia, impaired glucose tolerance; increased bone growth and skeletal weight; increase LDL cholesterol; increase haematocrit and fibrinolytic activity; headache, depression and GI bleeding.
Males: spermatogenesis suppression, priapism, gynaecomastia, prostatic hyperplasia and accelerate growth of malignant prostate neoplasms.
Females: suppression of lactation, ovarian activity and menstruation; virilization, clitoris hypertrophy, increased libido, oily skin, acne, hirsutism, male pattern baldness.
IM: urticaria, inflammation at Inj site, postinjection induration, furunculosis.
Potentially Fatal: Peliosis hepatis, liver toxicity, malignant neoplasm.
Mechanism of Action
Testosterone is the principal endogenous androgen responsible for promoting the growth and development of male sexual organs and maintaining secondary sex characteristics in androgen-deficient males.