Tetracycline Hydrochloride 1% Eye prep

Indications

Tetracycline Hydrochloride 1% Eye prep is used for: Bacterial Conjunctivitis

Adult Dose

Ophthalmic Adults: Apply every two to four hours.

Child Dose

Ophthalmic Children: Apply every two to four hours.

Renal Dose

Administration

First, wash hands. Then pull the lower eyelid away from the eye to form a pouch. Squeeze a thin strip of ointment into the pouch. A 1-cm (approximately 1/3-inch) strip of ointment is usually enough. Gently close the eyes and keep them closed for 1 or 2 minutes to allow the medicine to come into contact with the infection.

Contra Indications

Hypersensitivity; pregnancy, lactation, children; renal impairment.

Precautions

Hepatic impairment. Avoid exposure to sunlight. Periodic evaluation of renal, hepatic and haematological system during prolonged therapy.

Pregnancy-Lactation

Interactions

Impaired absorption w/ antacids containing divalent and trivalent cations (e.g. Al, Ca, Mg), Fe, Zn and Na bicarbonate preparations, kaolin-pectin, bismuth subsalicylate, sucralfate, strontium ranelate, colestipol and colestyramine. May interfere w/ the bactericidal action of penicillin. May potentiate the effect of anticoagulants. May decrease efficacy of oral contraceptives. Nephrotoxic effects may be exacerbated by diuretics or other nephrotoxic drugs. May increase the hypoglycaemic effect of insulin and sulfonylureas in patients w/ DM. May increase toxic effects of ergot alkaloids and methotrexate. Potentially Fatal: Concurrent methoxyflurane may result to fatal renal toxicity. Increased risk of benign intracranial HTN w/ vit A or retinoids (e.g. acitretin,isotretinoin, tretinoin).

Adverse Effects

Side effects of Tetracycline Hydrochloride 1% Eye prep : Burning, irritation, visual disturbances, superinfections, photosensitivity, hypersensitivity,

Mechanism of Action

Tetracycline exhibits its bacteriostatic action by reversibly binding to the 30S subunits of the ribosome, thus preventing protein synthesis and arresting cell growth. It has a broad spectrum of antimicrobial activity including Chlamydiaceae, Mycoplasma spp., Rickettsia spp., spirochaetes, many aerobic and anaerobic gm+ve and gm-ve pathogenic bacteria and some protozoa.