Tetracycline Hydrochloride 3% Eye prep
Indications
Tetracycline Hydrochloride 3% Eye prep is used for:
Bacterial Conjunctivitis
Adult Dose
Adult: Apply 2 hourly in acute eye infection.
Child Dose
Child: Apply 2 hourly in acute eye infection.
Renal Dose
Administration
Contra Indications
This drug is contraindicated in persons who have shown hypersensitivity to any of the tetracyclines.
Precautions
Hepatic impairment. Avoid exposure to sunlight. Periodic evaluation of renal, hepatic and haematological system during prolonged therapy.
Pregnancy-Lactation
Interactions
Impaired absorption w/ antacids containing divalent and trivalent cations (e.g. Al, Ca, Mg), Fe, Zn and Na bicarbonate preparations, kaolin-pectin, bismuth subsalicylate, sucralfate, strontium ranelate, colestipol and colestyramine. May interfere w/ the bactericidal action of penicillin. May potentiate the effect of anticoagulants. May decrease efficacy of oral contraceptives. Nephrotoxic effects may be exacerbated by diuretics or other nephrotoxic drugs. May increase the hypoglycaemic effect of insulin and sulfonylureas in patients w/ DM. May increase toxic effects of ergot alkaloids and methotrexate.
Potentially Fatal: Concurrent methoxyflurane may result to fatal renal toxicity. Increased risk of benign intracranial HTN w/ vit A or retinoids (e.g. acitretin,isotretinoin, tretinoin).
Adverse Effects
Side effects of Tetracycline Hydrochloride 3% Eye prep :
Burning, irritation, visual disturbances, superinfections, photosensitivity, hypersensitivity,
Mechanism of Action
Tetracycline exhibits its bacteriostatic action by reversibly binding to the 30S subunits of the ribosome, thus preventing protein synthesis and arresting cell growth. It has a broad spectrum of antimicrobial activity including Chlamydiaceae, Mycoplasma spp., Rickettsia spp., spirochaetes, many aerobic and anaerobic gm+ve and gm-ve pathogenic bacteria and some protozoa.