Thiamine (as nitrate), Pyridoxine (as HCl), Cyanocobalamin
Indications
Thiamine (as nitrate), Pyridoxine (as HCl), Cyanocobalamin is used for:
THIAMINE
For the treatment of thiamine and niacin deficiency states, korsakov's alcoholic psychosis, wernicke-korsakov syndrome, delirium, and peripheral neuritis
PYRIDOXINE
For the treatment of vitamin b6 deficiency and for the prophylaxis of isoniazid-induced peripheral neuropathy
CYANOCOBALAMIN
For treatment of pernicious anemia (due to lack of or inhibition of intrinsic factor) and for prevention and treatment of vitamin b 12 deficiency
For the treatment of thiamine and niacin deficiency states, korsakov's alcoholic psychosis, wernicke-korsakov syndrome, delirium, and peripheral neuritis
PYRIDOXINE
For the treatment of vitamin b6 deficiency and for the prophylaxis of isoniazid-induced peripheral neuropathy
CYANOCOBALAMIN
For treatment of pernicious anemia (due to lack of or inhibition of intrinsic factor) and for prevention and treatment of vitamin b 12 deficiency
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Thiamine (as nitrate), Pyridoxine (as HCl), Cyanocobalamin :
Mechanism of Action
THIAMINE
It is thought that the mechanism of action of thiamine on endothelial cells is related to a reduction in intracellular protein glycation by redirecting the glycolytic flux. Thiamine is mainly the transport form of the vitamin, while the active forms are phosphorylated thiamine derivatives. There are five known natural thiamine phosphate derivatives: thiamine monophosphate (thmp), thiamine diphosphate (thdp), also sometimes called thiamine pyrophosphate (tpp), thiamine triphosphate (thtp), and the recently discovered adenosine thiamine triphosphate (athtp), and adenosine thiamine diphosphate. Each derivative has unique functions, however, most are involved as coenzymes
PYRIDOXINE
Vitamin b6 is the collective term for a group of three related compounds, pyridoxine (pn), pyridoxal (pl) and pyridoxamine (pm), and their phosphorylated derivatives, pyridoxine 5'-phosphate (pnp), pyridoxal 5'-phosphate (plp) and pyridoxamine 5'-phosphate (pmp). Although all six of these compounds should technically be referred to as vitamin b6, the term vitamin b6 is commonly used interchangeably with just one of them, pyridoxine. Vitamin b6, principally in its biologically active coenzyme form pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (gaba)
CYANOCOBALAMIN
Vitamin b12 is used in the body in two forms: methylcobalamin and 5-deoxyadenosyl cobalamin. The enzyme methionine synthase needs methylcobalamin as a cofactor. This enzyme is involved in the conversion of the amino acid homocysteine into methionine. Methionine in turn is required for dna methylation. 5-deoxyadenosyl cobalamin is a cofactor needed by the enzyme that converts l-methylmalonyl-coa to succinyl-coa. This conversion is an important step in the extraction of energy from proteins and fats. Furthermore, succinyl coa is necessary for the production of hemoglobin, the substances that carries oxygen in red blood cells
It is thought that the mechanism of action of thiamine on endothelial cells is related to a reduction in intracellular protein glycation by redirecting the glycolytic flux. Thiamine is mainly the transport form of the vitamin, while the active forms are phosphorylated thiamine derivatives. There are five known natural thiamine phosphate derivatives: thiamine monophosphate (thmp), thiamine diphosphate (thdp), also sometimes called thiamine pyrophosphate (tpp), thiamine triphosphate (thtp), and the recently discovered adenosine thiamine triphosphate (athtp), and adenosine thiamine diphosphate. Each derivative has unique functions, however, most are involved as coenzymes
PYRIDOXINE
Vitamin b6 is the collective term for a group of three related compounds, pyridoxine (pn), pyridoxal (pl) and pyridoxamine (pm), and their phosphorylated derivatives, pyridoxine 5'-phosphate (pnp), pyridoxal 5'-phosphate (plp) and pyridoxamine 5'-phosphate (pmp). Although all six of these compounds should technically be referred to as vitamin b6, the term vitamin b6 is commonly used interchangeably with just one of them, pyridoxine. Vitamin b6, principally in its biologically active coenzyme form pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (gaba)
CYANOCOBALAMIN
Vitamin b12 is used in the body in two forms: methylcobalamin and 5-deoxyadenosyl cobalamin. The enzyme methionine synthase needs methylcobalamin as a cofactor. This enzyme is involved in the conversion of the amino acid homocysteine into methionine. Methionine in turn is required for dna methylation. 5-deoxyadenosyl cobalamin is a cofactor needed by the enzyme that converts l-methylmalonyl-coa to succinyl-coa. This conversion is an important step in the extraction of energy from proteins and fats. Furthermore, succinyl coa is necessary for the production of hemoglobin, the substances that carries oxygen in red blood cells