Tolperisone Hydrochloride
Indications
Tolperisone Hydrochloride is used for:
Painful muscle spasm associated with disorders of the locomotor system:
Low back pain, sciatica, overstrain of joints, osteoarthritis, rheumatoid arthritis, herniated disc, spondylosis, nerve root compression caused by osteoporosis, soft tissue inflammation (bursitis, periarthritis, humeroscapsularis).
Muscle spasticity associated with neurological conditions:
Stroke induced hemiparesis or hemiplegia, pyramidal tract lesion, multiple sclerosis, myelopathies, encephalomyelitis, spinal automatisms, paralysis spinalis spastica, cerebral palsy.
Decreased peripheral circulation as seen in:
Atherosclerosis obliterans, endarteritis obliterans, thromboangitis obliterans, Raynaud's disease, acrocyanosis, intermittent angioneurotic dysbasia.
Special paediatric indications:
Little's disease (spastic paralysis) and other encephalopathies accompanied by dystonia.
Rehabilitation:
Treatment after limb fractures followed by long term fixation, postoperative therapy of traumatological and orthopedic limb surgery, rehabilitation of hemiplegic patients.
Adult Dose
Oral
Spasticity ; Muscle spasms
Adult: 50-150 mg tid.
Intramuscular
Adult: One ampoule twice daily.
Injection should be given slowly.
Child Dose
Oral
Spasticity ; Muscle spasms
Child: <6 yr: 5 mg/kg daily in 3 divided doses;
6-14 yr: 2-4 mg/kg daily in 3 divided doses.
Renal Dose
Administration
Should be taken with food.
Contra Indications
Hypersensitivity to any component of the product
Myasthenia gravis, Nursing mother
Precautions
In case of children, the prescribed dose and duration of treatment should closely be observed.
Pregnancy-Lactation
Interactions
Methocarbamol. Tolperisone HCl.
Adverse Effects
Side effects of Tolperisone Hydrochloride :
Sometimes, muscular weakness, headache, nausea, vomiting and rarely hypersensitivity reactions may occur as side effects.
Mechanism of Action
Tolperisone is a centrally acting muscle relaxant.