Travoprost 0.004% Eye prep

Indications

Travoprost 0.004% Eye prep is used for: Ocular hypertension, Open-angle glaucoma

Adult Dose

Ophthalmic Ocular hypertension; Open-angle glaucoma Adult: As 0.004% soln: Instill 1 drop in the conjunctival sac of the affected eye(s) once daily, preferably in the evening.

Child Dose

Safety and efficacy not established

Renal Dose

Administration

Contra Indications

Hypersensitivity, Pregnancy

Precautions

Aphakic patient, pseudophakic patient w/ torn posterior lens capsule or anterior chamber lenses, or w/ known risk factor for cystoid macular oedema. Patient w/ history of intraocular inflammation (e.g. uveitis, iritis). Pregnancy and lactation. Patient Counselling Remove contact lenses prior to admin and reinsert after 15 min. Lactation: distributed in milk in animals; caution if used in nursing women

Pregnancy-Lactation

Pregnancy Category: C Lactation: distributed in milk in animals; caution if used in nursing women

Interactions

Reduced therapeutic effect w/ NSAIDs.

Adverse Effects

Side effects of Travoprost 0.004% Eye prep : >10% Increased pigmentation of iris & periorbital tissue & increased pigmentation, thickening, elongation & growth of eyelashes (59%), Ocular hyperemia (35-50%) 1-10% Decreased visual acuity (5-10%), Ocular discomfort (5-10%), Foreign body sensation (5-10%), Pain (5-10%), Pruritus (5-10%), Abnormal vision (1-4%), Blepharitis (1-4%), Blurred vision (1-4%), Cataract (1-4%), Conjunctivitis (1-4%), Dry eye (1-4%), Iris discoloration (1-4%), Keratitis (1-4%), Lid margin crusting (1-4%), Photophobia (1-4%), Subconjunctival hemorrhage (1-4%), Tearing (1-4%)

Mechanism of Action

Travoprost, a synthetic analogue of prostaglandin F2α, reduces intraocular pressure by increasing uveoscleral outflow of aqueous humour.