Triamcinolone Acetonide Inhalation

Indications

Triamcinolone Acetonide Inhalation is used for: Prophylaxis treatment of Asthma

Adult Dose

Asthma Inhaler: 1 puff (200mcg) 2-3 times daily. No more than 6 puffs(1200 mcg) /day.

Child Dose

Asthma >12 years old: 1 puff (200mcg) 2-3 times daily. No more than 4 puffs/day

Renal Dose

Administration

Contra Indications

Triamcinolone acetonide (inhalation aerosol) Inhalation Aerosol is not to be regarded as a bronchodilator and is not indicated for rapid relief of bronchospasm. Triamcinolone Acetonide is contraindicated in patients with a sensitivity to the active or inactive ingredients. Untreated systemic fungal, bacterial, viral or parasitic infection.

Precautions

Particular care is needed in patients who are transferred from systemically active corticosteroids to (triamcinolone acetonide (inhalation aerosol)) Inhalation Aerosol because deaths due to adrenal insufficiency have occurred in asthmatic patients during and after transfer from systemic corticosteroids to aerosolized steroids in recommended doses. Orally inhaled corticosteroids may cause a reduction in growth velocity when administered to pediatric patients. TB, other serious infections, Glaucoma, incr IOP, cataracts, immunocompromised pts.

Pregnancy-Lactation

Pregnancy Category: C Lactation: not known if excreted in breast milk

Interactions

Lowering of plasma salicylates levels. Increased risk of GI bleeding and ulceration with NSAIDs. Antagonised blood glucose-lowering effects of the antidiabetics. Increased risk of hyperkalaemia with amphotericin B, beta agonists, beta-blockers, potassium-depleting diuretics, theophylline. Increased clearance of the triamcinolone with ciclosporin, carbamazepine, phenytoin, barbiturate, rifampicin. Infections may develop if given with live vaccines.

Adverse Effects

Side effects of Triamcinolone Acetonide Inhalation : >10% Pharyngitis (25%), Headache (21%) 1-10% Flu syndrome (5%), Sinusitis (4%), Back pain (2%) Frequency Not Defined Bronchospasm, Cough, Dry throat/mouth, Oral candidiasis (rare)

Mechanism of Action

Triamcinolone has mainly glucocorticoid activity. It suppresses the migration of polymorphonuclear leukocytes and reduces capillary permeability thereby decreasing inflammation.