Trifluridine 1% Eye prep
Indications
Trifluridine 1% Eye prep is used for:
Keratoconjunctivitis, recurrent epithelial keratitis, due to herpes simplex viruses
Adult Dose
Ophthalmic
Primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex viruses
Adult: As 1% soln: Instill 1 drop into affected eye 2 hrly. Max: 9 drops daily, until complete re-epithelialisation. Reduce to 1 drop 4 hrly (Min 5 drops daily) for 7 days. Treatment should not exceed 21 days.
Child Dose
Ophthalmic
Primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex viruses
Child: >6 yr: Instill 1 drop into affected eye 2 hrly. Max: 9 drops daily, until complete re-epithelialisation. Reduce to 1 drop 4 hrly (Min 5 drops daily) for 7 days. Treatment should not exceed 21 days.
Renal Dose
Administration
Contra Indications
Hypersensitivity.
Precautions
Pregnancy; child <6 yr. Use under close supervision of ophthalmologist. Continuous admin >21 days to be avoided due to risk of ocular toxicity.
Pregnancy-Lactation
Pregnancy Category: C
Lactation: unlikely to be distributed into breast milk; use caution
Interactions
Adverse Effects
Side effects of Trifluridine 1% Eye prep :
Transient burning or stinging upon instillation, irritation, hyperemia, palpebral oedema, dry eye, superficial punctate keratopathy, epithelial keratopathy, hypersensitivity reaction and increased intraocular pressure.
Mechanism of Action
Trifluridine interferes with the synthesis of viral DNA following phosphorylation. It is active against HSV types 1 and 2 and vaccinia virus.