Triprolidine

Indications

Triprolidine is used for: Allergic Rhinitis

Adult Dose

Allergic Rhinitis Indicated for temporary relief of rhinorrhea, sneezing, itchy nose, throat, or eyes owing to have fever or other upper respiratory allergies or allergic rhinitis Syrup 0.5mg/ml: 2.5 mg (5 mL) PO q6hr

Child Dose

Allergic Rhinitis Indicated for temporary relief of rhinorrhea, sneezing, itchy nose, throat, or eyes owing to have fever or other upper respiratory allergies or allergic rhinitis Syrup 0.5mg/ml: <6 years: As directed by physician 6 to <12 years: 1.25 mg (2.5 mL) PO q6hr prn >12 years: 2.5 mg (5 mL) PO q6hr

Renal Dose

Administration

Do not exceed 4 doses in 24 hr or as directed by physician Administer only with enclosed dropper or measuring device supplied with specific product

Contra Indications

Patients taking sedatives or tranquilizers Hypersensitivity; note that cross allergenicity may occur between chemically similar antihistamines

Precautions

May cause CNS depression, resulting in impaired physical or mental abilities; caution patients about performing tasks that require mental alertness (eg, driving, operating machinery) Antihistamines may cause excitation in young children Discontinue and contact physician if symptoms persist beyond 7 days or are accompanied by fever Discontinue and contact physician if nervousness, dizziness, or sleeplessness occur Do not exceed recommended dose

Pregnancy-Lactation

Pregnancy Limited data exist Generally, antihistamines are considered low risk during pregnancy; however, exposure near birth of premature infants was associated with increased risk of retrolental fibroplasia Lactation Distributed in human breast milk; small, occasional doses are not expected to cause adverse effects in infant Larger doses may cause irritability or colicky symptoms in infant or decrease milk production in mother; nonsedating antihistamines are preferred during breastfeeding Consider the developmental and health benefits of breastfeeding along with the mother’s clinical need for the drug, and any potential adverse effects on the breastfed infant from the drug or from the underlying maternal condition

Interactions

Adverse Effects

Side effects of Triprolidine : Frequency Not Defined Blurred vision Sedation Urinary retention Constipation Xerostomia

Mechanism of Action

First generation histamine-1 receptor antagonist