Urea (as 14C-Urea)
Indications
Urea (as 14C-Urea) is used for:
Urea-13c is indicated for use in the qualitative detection of urease associated with helicobacter pylori in the human stomach and as an aid in the initial diagnosis and post-treatment monitoring of helicobacter pylori infection in adult patients. The test may be used for monitoring treatment if used at least four (4) weeks following completion of therapy. For these purposes, the system utilizes an infrared spectrophotometer for the measurement of the ratio of 13co2 to 12co2 in breath samples
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Urea (as 14C-Urea) :
Mechanism of Action
The urea breath test is based on the ability of the h. Pylori enzyme urease to cleave urea into ammonia and carbon dioxide. As the urease enzyme is not present in mammalian cells, the presence of urease (and the products of urea cleavage) in the stomach is evidence that h. Pylori bacteria are present. To detect h. Pylori, urea labeled with 13c is swallowed by the patient. If gastric urease from h. Pylori is present, urea is split to form co2 and nh3 at the interface between the gastric epithelium and lumen and 13co2 is absorbed into the blood and exhaled in the breath. Exhaled breath samples can then be collected and measured for the presence of radioactivity