Vitamin B1 + Vitamin B2 + Vitamin B6 + Nicotinamide
Indications
Vitamin B1 + Vitamin B2 + Vitamin B6 + Nicotinamide is used for:
Skin & nervous system, fertility, sciatica, lumbago, trigeminal neuralgia, facial paralysis, optic neuritis, diabetic neuropathy, peripheral neuralgia, myalgia
Adult Dose
Oral
Adult:
Syrup : 1-2 (5 ml spoonful) syrup three times a day.
Child Dose
Oral
Children: 1 (5 ml spoonful) syrup three times a day.
Renal Dose
Administration
Contra Indications
Contraindicated in patients hypersensitive to any of its components.
Precautions
Pregnancy-Lactation
Interactions
Pyridoxine: Isoniazid, penicillamine and oral contraceptives may result in greater requirement in pyridoxine dose. Reduces the effects of levodopa, phenobarbitone, altretamine and phenytoin.
Riboflavin: Rate and extent of absorption may be affected by propantheline bromide.
Adverse Effects
Side effects of Vitamin B1 + Vitamin B2 + Vitamin B6 + Nicotinamide :
Generally well tolerated.
Mechanism of Action
Vitamin B: Plays a role in the synthesis and maintenance of coenzyme A. Necessary for lipid metabolism, carbohydrate metabolism, tissue respiration, glycogenolysis, inhibition of very low-density lipoprotein (VLDL) synthesis. May increase chylomicron triglyceride removal from plasma.
Pyridoxine (vitamin B6) is a water-soluble vitamin which functions in the metabolism of carbohydrates, proteins and fats. It is essential in Hb formation and GABA synthesis within the CNS. It also aids in the release of glycogen stored in the liver and muscles.
Riboflavin (vitamin B2) is required for energy utilisation from food. It is essential for normal tissue respiration. It is also necessary for the activation of pyridoxine and conversion of tryptophan to nicotinic acid.
Vitamin B1 forms thiamine pyrophosphate by combining with adenosine triphosphate; essential coenzyme in carbohydrate metabolism.