Voglibose

Indications

Voglibose is used for: Diabetes mellitus

Adult Dose

Oral Diabetes mellitus Adult: 200-300 mcg tid. Elderly: Initiate at lower doses.

Child Dose

Renal Dose

Administration

Should be taken with food. Take just before meals.

Contra Indications

Inflammatory bowel disease; GI obstruction or patients predisposed to it; conditions which may deteriorate as a result of increased gas formation eg, hernia; severe ketosis; diabetic coma or pre-coma; severe infection; hypersensitivity; pregnancy; lactation. Not to be used as monotherapy in IDDM.

Precautions

History of laparotomy or ileus. Roemheld's syndrome, stenosis, severe hepatic or renal impairment. Child <18 yr; elderly. Monitor LFT. Treat hypoglycaemic episodes with glucose (not with sucrose).

Pregnancy-Lactation

Interactions

May enhance effects of other antidiabetics including insulin.

Adverse Effects

Side effects of Voglibose : Flatulence; abdominal distension; diarrhoea; pain; skin reactions; hypoglycemia; increased LFT. Potentially Fatal: Hepatotoxicity.

Mechanism of Action

Voligbose has general properties similar to acarbose and selectively inhibits α-glucosidase in the enteric canal, delaying the digestion and absorption of carbohydrate, thereby suppressing sharp increase in post-prandial plasma glucose.