Amlohope 10/10 Capsules (Hard Gelatin)
Amlodipine + Ramipril
"10mg,10mg"
Hexal AG
| Pack size | 30's (10's Blister x 3) |
|---|---|
| Dispensing mode | POM |
| Source | GERMANY |
| Agent | ALPHAMED CO. (AUH) LTD. |
| Retail Price | 104.50 AED |
Available as:
Indications
Amlohope 10/10 Capsules (Hard Gelatin) is used for:
Essential hypertension in patients:
whose blood pressure is not adequately controlled on amlodipine or ramipril
OR
already controlled with ramipril and amlodipine given concurrently at the same dose
Adult Dose
By mouth, 1 tablet once daily
Child Dose
Renal Dose
Renal impairment:
CrCl 10-60 mL/min and haemodialysis: Maximum of 5 mg (Ramipril) once daily
Administration
For Oral use
Contra Indications
Hypersensitivity to amlodipine, ramipril, any of the excipients, dihydropyridine derivatives, or angiotensin converting enzyme (ACE) inhibitors
Pregnancy
History of angioedema associated with previous ACE inhibitor
Hereditary or idiopathic angioedema.
Concurrent use with aliskiren in patients with diabetes or moderate to severe renal impairment (GFR less than 60 mL/min)
Significant bilateral renal artery stenosis or renal artery stenosis in a single functioning kidney
Severe hypotension
Shock
Haemodynamically unstable state
Obstruction of the outflow-tract of the left ventricle; Mitral valve stenosis
Breastfeeding is not recommended
Precautions
Heart failure
Concurrent use with drugs that affect the renin-angiotensin system
Renal impairment
Hepatic impairment
Patients with strongly activated renin-angiotensin-aldosterone system
Severe volume or salt depletion
Hyponatremia
Pregnancy-Lactation
Interactions
Dantrolene: Concurrent use is contraindicated. Increases risk of cardiovascular collapse.
Angiotensin receptor blockers; Aliskiren: Concurrent use is contraindicated in patients with diabetic nephropathy and is not recommended in other patients. May increase risk of hyperkalaemia, hypotension, and syncope.
Sacubitril/valsartan: Concurrent use is contraindicated. Increases risk of angioedema.
Simvastatin: Significantly increases simvastatin concentrations. When used concurrently, maximum simvastatin dose should be 20mg.
mTOR inhibitors, such as sirolimus and everolimus: Concurrent use increases risk of angioedema.
Tissue Plasminogen Activators: Concurrent use increases risk of angioedema.
Co-trimoxazole (trimethoprim/sulfamethoxazole): Concurrent use increases risk for hyperkalaemia.
Lithium: Increases lithium concentrations and may cause lithium toxicity. Concurrent use is not recommended.
Drugs that can cause hyperkalaemia, such as potassium supplements and potassium-sparing diuretics: Increases risk of hyperkalaemia.
Allopurinol, immunosuppressants, corticosteroids, procainamide, cytostatics, and other substances that may change the blood cell count:
Increases risk of haematological reactions, such as agranulocytosis and neutropenia.
NSAIDs: Increases risk of renal impairment. NSAIDs decrease efficacy of this medication. Use with caution.
Strong or moderate CYP3A4 inhibitors, such as protease inhibitors, azole antifungals, clarithromycin, and erythromycin: May increase amlodipine concentrations.
CYP3A4 inducers: May decrease amlodipine concentrations
Adverse Effects
Side effects of Amlodipine + Ramipril :
Common adverse effects:
Orthostatic hypotension
Flushing
Cough; Bronchitis; Sinusitis; Dyspnoea
Abdominal pain; Nausea; Vomiting; Diarrhoea
Oedema; Fatigue; Chest pain
Somnolence; Dizziness; Headache
Muscle spasms;Myalgia
Palpitations
Renal impairment
Elevated serum potassium
Maculopapular rash
Uncommon adverse effects:
Allergic reactions
Hypersensitivity/angioneurotic oedema: angioneurotic oedema of the face, extremities, lips, tongue, glottis, and/or larynx
Asthenia; Pain; Malaise
Hypotension; Vasculitis
Rhinitis
Dyspepsia; Altered bowel habits; Dry mouth
Tremor; Dysgeusia; Syncope; Hypoesthesia; Paraesthesia
Pancreatitis; Gastritis; Intestinal angioedema
Gingival hyperplasia
Hepatitis; Jaundice; Elevated hepatic enzymes
Uraemia; Acute renal failure; Oliguria; Anuria
Alopecia; Purpura; Skin discolouration; Hyperhidrosis; Pruritus; Exanthema
Angioedema; Erythema; Multiforme; Urticaria; Exfoliative dermatitis;
Stevens-Johnson syndrome; Quincke oedema
Photosensitivity
Arthralgia; Muscle cramps; Back pain
Micturition disorder; Nocturia; Increased urinary frequency
Impotence; Gynecomastia
Leukocytopenia; Thrombocytopenia
Hyperglycaemia; Hypoglycaemia
Insomnia; Mood changes; Anxiety; Depression; Confusion
Visual disturbances
Tinnitus
Myocardial infarction, arrhythmia
Syndrome of inappropriate antidiuretic hormone secretion (SIADH)
Elevated blood urea, serum creatinine, serum bilirubin
Hyponatraemia
Decreased haemoglobin, haematocrit.
Bone marrow depression; Anaemia; Thrombocytopenia; Leucopoenia; Neutropenia; Agranulocytosis; Haemolytic anaemia; Lymphadenopathy; Autoimmune disease
Mechanism of Action
Note
Amlohope 10/10 "10mg,10mg" Capsules (Hard Gelatin) manufactured by Hexal AG. Its generic name is Amlodipine + Ramipril. Amlohope 10/10 is availble in United Arab Emirates.
Farmaco UAE drug index information on Amlohope 10/10 Capsules (Hard Gelatin) is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.