Dalacin T 1% Topical Solution

Clindamycin 1% Topical
10mg/ml
UPJOHN CO.
Pack size 60ml Bottle
Dispensing mode POM
Source USA
AgentModern Pharmaceutical Co.
Retail Price 60.00 AED

Indications

Dalacin T 1% Topical Solution is used for: Acne vulgaris, erythrasma, rosacea, periorificial dermatitis, folliculitis, stasis, chronic lymphaedema and familial pemphigus, dermal ulcers.

Adult Dose

Topical/Cutaneous Acne Adult: As 1% preparation: Apply a thin layer onto affected area bid.

Child Dose

<12 years old Safety and efficacy not established >12 years: Apply a thin layer onto affected area bid.

Renal Dose

Administration

Contra Indications

Contraindicated in patients with hypersensitivity to clindamycin.

Precautions

It is not for oral, ophthalmic, or Intravaginal use. Avoid exposure to sunlight and sunlamps. Wear sunscreen daily. Lactation: Excretion in milk unknown; use with caution

Pregnancy-Lactation

Pregnancy In clinical trials with pregnant women, systemic administration of clindamycin during second and third trimesters has not been associated with increased frequency of congenital abnormalities; there are no adequate studies in pregnant women during first trimester of pregnancy; clindamycin should be used during first trimester of pregnancy only if clearly needed Lactation Not known whether clindamycin is excreted in human milk following therapy; however, orally and parenterally administered clindamycin has been reported to appear in breast milk; clindamycin has potential to cause adverse effects on breastfed infant's gastrointestinal flora; if oral or intravenous clindamycin is required by a nursing mother, it is not a reason to discontinue breastfeeding, but an alternate drug may be preferred; monitor infant for possible adverse effects on gastrointestinal flora, such as diarrhea, candidiasis (thrush, diaper rash) or rarely, blood in the stool indicating possible antibiotic-associated colitis Developmental and health benefits of breastfeeding should be considered along with mother's clinical need for clindamycin and any potential adverse effects on breastfed child from clindamycin or from underlying maternal condition

Interactions

May enhance the action of neuromuscular blocking agents (e.g. atracurium). May antagonise the effects of parasympathomimetics. May competitively inhibit the effects of macrolides, ketolides, streptogramins, linezolid and chloramphenicol. Increased coagulation tests (prothrombin time/INR) and/or bleeding w/ vit K antagonists (e.g. warfarin, acenocoumarol, fluindione).

Adverse Effects

Side effects of Clindamycin 1% Topical : >10% Dryness (18-23%), Oiliness (1-18%), Erythema (7-16%), Peeling (7-11%), Burning/itching (6-11%) 1-10% Headache (3%)

Mechanism of Action

Clindamycin inhibits protein synthesis by reversibly binding to the 50S subunit of the ribosomal thus blocking the transpeptidation or translocation reactions of susceptible organisms resulting to stunted cell growth.

Note

Dalacin T 1% 10mg/ml Topical Solution manufactured by UPJOHN CO.. Its generic name is Clindamycin 1% Topical. Dalacin T 1% is availble in United Arab Emirates. Farmaco UAE drug index information on Dalacin T 1% Topical Solution is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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