Gelclair Gel (Oral Rinse) / Concentrate

Povidone, Sodium hyaluronate
"9%, 0.1%"
HELSINN HEALTHCARE SA
Pack size 180ml PET Bottle
Dispensing mode Pharmacy Only (P)
Source SWITZERLAND
AgentPHARMA SOLUTION DRUG STORE
Retail Price 124.00 AED

Indications

Gelclair Gel (Oral Rinse) / Concentrate is used for: Povidone-iodine
For topical application in the treatment and prevention of infection in wounds.

Adult Dose

Child Dose

Renal Dose

Administration

Contra Indications

Precautions

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Povidone, Sodium hyaluronate :

Mechanism of Action

Povidone-iodine
Povidone-iodine is called iodophore which means povidone acts as a carrier of iodine. Iodine is considered as the active moiety that mediates microbicidal actions. When released from the complex, free iodine (I2) penetrates the cell wall of microorganisms quickly, and the lethal effects are believed to result from disruption of protein and nucleic acid structure and synthesis. While the full mechanism of action is not fully elucidated, iodine is thought to inhibit vital bacterial cellular mechanisms and structures, and oxidizes nucleotides fatty or amino acids in bacterial cell membranes [A32992]. Additionally, free iodine disrupts the function of the cytosolic enzymes involved in the respiratory chain, causing them to become denatured and deactivated [A32992]. _In vitro_ evidence suggests that iodine also counteracts inflammation elicited by both pathogens and the host response via multifactorial effects. In hosts, povidone-iodine was demonstrated to modulate the redox potential, inhibit the release of inflammatory mediators such as TNF-a and ş-galactosidase, inhibit metalloproteinase production, and potentiate the healing signals from pro-inflammatory cytokines by activation of monocytes, T-lymphocytes, and macrophages, _in vitro_ [A32992].

Note

Gelclair "9%, 0.1%" Gel (Oral Rinse) / Concentrate manufactured by HELSINN HEALTHCARE SA. Its generic name is Povidone, Sodium hyaluronate. Gelclair is availble in United Arab Emirates. Farmaco UAE drug index information on Gelclair Gel (Oral Rinse) / Concentrate is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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