Gelclair Gel (Oral Rinse) / Concentrate
Povidone, Sodium hyaluronate
"9%, 0.1%"
HELSINN HEALTHCARE SA
| Pack size | 15ml Sachet x 21 |
|---|---|
| Dispensing mode | P |
| Source | SWITZERLAND |
| Agent | PHARMA SOLUTION DRUG STORE |
| Retail Price | 216.00 AED |
Available as:
Indications
Gelclair Gel (Oral Rinse) / Concentrate is used for:
Povidone-iodine
For topical application in the treatment and prevention of infection in wounds.
For topical application in the treatment and prevention of infection in wounds.
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Povidone, Sodium hyaluronate :
Mechanism of Action
Povidone-iodine
Povidone-iodine is called iodophore which means povidone acts as a carrier of iodine. Iodine is considered as the active moiety that mediates microbicidal actions. When released from the complex, free iodine (I2) penetrates the cell wall of microorganisms quickly, and the lethal effects are believed to result from disruption of protein and nucleic acid structure and synthesis. While the full mechanism of action is not fully elucidated, iodine is thought to inhibit vital bacterial cellular mechanisms and structures, and oxidizes nucleotides fatty or amino acids in bacterial cell membranes [A32992]. Additionally, free iodine disrupts the function of the cytosolic enzymes involved in the respiratory chain, causing them to become denatured and deactivated [A32992]. _In vitro_ evidence suggests that iodine also counteracts inflammation elicited by both pathogens and the host response via multifactorial effects. In hosts, povidone-iodine was demonstrated to modulate the redox potential, inhibit the release of inflammatory mediators such as TNF-a and ş-galactosidase, inhibit metalloproteinase production, and potentiate the healing signals from pro-inflammatory cytokines by activation of monocytes, T-lymphocytes, and macrophages, _in vitro_ [A32992].
Povidone-iodine is called iodophore which means povidone acts as a carrier of iodine. Iodine is considered as the active moiety that mediates microbicidal actions. When released from the complex, free iodine (I2) penetrates the cell wall of microorganisms quickly, and the lethal effects are believed to result from disruption of protein and nucleic acid structure and synthesis. While the full mechanism of action is not fully elucidated, iodine is thought to inhibit vital bacterial cellular mechanisms and structures, and oxidizes nucleotides fatty or amino acids in bacterial cell membranes [A32992]. Additionally, free iodine disrupts the function of the cytosolic enzymes involved in the respiratory chain, causing them to become denatured and deactivated [A32992]. _In vitro_ evidence suggests that iodine also counteracts inflammation elicited by both pathogens and the host response via multifactorial effects. In hosts, povidone-iodine was demonstrated to modulate the redox potential, inhibit the release of inflammatory mediators such as TNF-a and ş-galactosidase, inhibit metalloproteinase production, and potentiate the healing signals from pro-inflammatory cytokines by activation of monocytes, T-lymphocytes, and macrophages, _in vitro_ [A32992].
Note
Gelclair "9%, 0.1%" Gel (Oral Rinse) / Concentrate manufactured by HELSINN HEALTHCARE SA. Its generic name is Povidone, Sodium hyaluronate. Gelclair is availble in United Arab Emirates.
Farmaco UAE drug index information on Gelclair Gel (Oral Rinse) / Concentrate is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.