Giotrif Tablets / Film-coated

Afatinib (as dimaleate)
30mg
Boehringer Ingelheim International GmbH
Pack size 28’s (7's Blister x 4)
Dispensing mode POM
Source GERMANY
AgentGULF DRUG L.L.C.
Retail Price 12023.00 AED

Indications

Giotrif Tablets / Film-coated is used for: Afatinib is a kinase inhibitor indicated for the first-line treatment of patient with metastatic non-small cell lung cancer (NSCLC) whose tumours have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution mutations as detected by an FDA-approved test.

Adult Dose

Child Dose

Renal Dose

Administration

Contra Indications

Precautions

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Afatinib (as dimaleate) :

Mechanism of Action

Afatinib is an irreversible kinase inhibitor and binds to the kinase domains of EGFR (ErbB1), HER2 (ErbB2), and HER4 (ErbB4) to inhibit tyrosine kinase autophosphorylation. This results in a downregulation of ErbB signalling and subsequent inhibition of proliferation of cell lines expressing wild-type EGFR, selected EGFR exon 19 deletion mutations, or exon 21 L858R mutations. It also inhibited in vitro proliferation of cell lines overexpressing HER2. Overall, tumour growth was inhibited.

Note

Giotrif 30mg Tablets / Film-coated manufactured by Boehringer Ingelheim International GmbH. Its generic name is Afatinib (as dimaleate). Giotrif is availble in United Arab Emirates. Farmaco UAE drug index information on Giotrif Tablets / Film-coated is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Afatinib (as dimaleate) :