Giotrif Tablets / Film-coated
Afatinib (as dimaleate)
50mg
Boehringer Ingelheim International GmbH
| Pack size | 28’s (7's Blister x 4) |
|---|---|
| Dispensing mode | POM |
| Source | GERMANY |
| Agent | GULF DRUG L.L.C. |
| Retail Price | 12023.00 AED |
Available as:
Indications
Giotrif Tablets / Film-coated is used for:
Afatinib is a kinase inhibitor indicated for the first-line treatment of patient with metastatic non-small cell lung cancer (NSCLC) whose tumours have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution mutations as detected by an FDA-approved test.
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Afatinib (as dimaleate) :
Mechanism of Action
Afatinib is an irreversible kinase inhibitor and binds to the kinase domains of EGFR (ErbB1), HER2 (ErbB2), and HER4 (ErbB4) to inhibit tyrosine kinase autophosphorylation. This results in a downregulation of ErbB signalling and subsequent inhibition of proliferation of cell lines expressing wild-type EGFR, selected EGFR exon 19 deletion mutations, or exon 21 L858R mutations. It also inhibited in vitro proliferation of cell lines overexpressing HER2. Overall, tumour growth was inhibited.
Note
Giotrif 50mg Tablets / Film-coated manufactured by Boehringer Ingelheim International GmbH. Its generic name is Afatinib (as dimaleate). Giotrif is availble in United Arab Emirates.
Farmaco UAE drug index information on Giotrif Tablets / Film-coated is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.