Oxynorm Injection

Oxycodone HCl
10mg/ml
NAPP PHARMACEUTICALS LTD.
Pack size 2ml Ampoule x 5
Dispensing mode CD-Narcotic
Source UK
AgentCITY MEDICAL STORE
Retail Price 110.00 AED

Available as:

5mg - Capsules (Hard Gelatin) 20mg - Capsules (Hard Gelatin) 10mg/ml - Injection 10mg - Capsules (Hard Gelatin)

Indications

Oxynorm Injection is used for: For the treatment of diarrhoea, pulmonary oedema and for the relief of moderate to moderately severe pain.

Adult Dose

Child Dose

Renal Dose

Administration

Contra Indications

Precautions

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Oxycodone HCl :

Mechanism of Action

Oxycodone acts as a weak agonist at mu, kappa, and delta opioid receptors within the central nervous system (CNS). Oxycodone primarily affects mu-type opioid receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as oxycodone also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (kappa-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (mu and delta receptor agonist). This results in hyperpolarization and reduced neuronal excitability.

Note

Oxynorm 10mg/ml Injection manufactured by NAPP PHARMACEUTICALS LTD.. Its generic name is Oxycodone HCl. Oxynorm is availble in United Arab Emirates. Farmaco UAE drug index information on Oxynorm Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Oxycodone HCl :

Capsules (Hard Gelatin)
Oxynorm 5mg
NAPP PHARMACEUTICALS LTD.
Capsules (Hard Gelatin)
Oxynorm 20mg
NAPP PHARMACEUTICALS LTD.
Injection
Oxynorm 10mg/ml
NAPP PHARMACEUTICALS LTD.
Tablets / Controlled-release
Oxycontin 80mg
PURDUE PHARMACEUTICALS LP
Capsules (Hard Gelatin)
Oxynorm 10mg
NAPP PHARMACEUTICALS LTD.