Predo Syrup
Prednisolone
3mg/ml
Jazeera Pharmaceutical Industries
| Pack size | 120ml Glass Bottle |
|---|---|
| Dispensing mode | POM |
| Source | SAUDI ARABIA |
| Agent | GULF DRUG EST. |
| Retail Price | 42.50 AED |
Predo Overview
Predo generic name is Prednisolone. Prednisolone is a steroid medication that is used to treat a wide variety of inflammatory and immune-mediated conditions, including allergic disorders, skin conditions, respiratory diseases, blood disorders, and certain types of cancer. It works by reducing inflammation and suppressing the immune system. Prednisolone is available in both oral and intravenous forms and can also be used as an eye drop or an inhaler.
Prednisolone can cause serious side effects, especially if taken for a long time or at a high dose, such as weight gain, diabetes, osteoporosis, high blood pressure, cataracts, and increased risk of infections.
It's important to take prednisolone exactly as prescribed by your doctor and to follow the recommended dosage schedule. Your doctor may need to monitor your blood sugar and bone density while you are taking this medication. It's also essential to inform your doctor if you are pregnant, breastfeeding or planning to become pregnant.
Indications
Predo Syrup is used for:
Allergic and inflammatory disorders, Rheumatoid arthritis, Multiple sclerosis, Nephrotic syndrome, Joint inflammations, Idiopathic thrombocytopenic purpura, Moderate to severe asthma, Infantile spasms
Adult Dose
Oral
Allergic and inflammatory disorders
Adult: 5-60 mg daily in 2-4 divided doses. Maintenance: 2.5-15 mg daily. Withdrawal should be gradual after long-term therapy.
Poorly controlled, moderate to severe asthma, COPD
Adult: Patients with at least 2 exacerbations/yr requiring oral corticosteroids: 40-60 mg daily in 1-2 divided doses; usually given as a short course treatment over 10-14 days until symptom resolution and patient achieves a peak expiratory flow (PEF) of at least 80% of his or her personal best.
Rheumatoid arthritis
Adult: Initially, 5-7.5 mg daily, adjusted as necessary.
Elderly: 5 mg daily.
Multiple sclerosis
Adult: 200 mg daily for 1 wk followed by 80 mg every other day for 1 mth.
Bells Palsy
60 mg PO qDay for 5 days;
then taper down by 10 mg daily for 5 days for total duration time of 10 days
Child Dose
Inflammation
0.1-2 mg/kg/day PO in single daily dose or divided q6-12hr; not to exceed 80 mg/day
Acute Asthma
1-2 mg/kg/day in single daily dose or divided q12hr for 3-5 days
Nephrotic Syndrome
First 4 weeks: 60 mg/m²/day or 2 mg/kg/day PO divided q8hr until urine is protein free for 3 consecutive days; not to exceed 28 days; dose not to exceed 80 mg/day
Subsequent 4 weeks: 40 mg/m² or 1-1.5 mg/kg PO every other day; not to exceed 80 mg/day
Maintenance in frequent relapses: 0.5-1 mg/kg/dose PO every other day for 3-6 months
Idiopathic thrombocytopenic purpura
Child: 1-10 yr: 1-2 mg/kg daily (max: 14 days) or 4 mg/kg daily (max: 4 days).
Renal Dose
Administration
Should be taken with food.
Contra Indications
- Herpes simplex keratitis
- Live vaccines
- Systemic infections
Precautions
Patients with hypothyroidism, ulcerative colitis, cirrhosis, CHF, convulsive disorders, peptic ulcer, thrombophlebitis, elderly.
DM, hypertension, psychological disturbances, osteoporosis;
Adrenal suppression and infection.
May cause irreversible growth retardation, glaucoma, corneal perforation.
Pregnancy, lactation.
Lactation: Excreted in breast milk; use caution
Pregnancy-Lactation
Pregnancy
Prednisolone shown to be teratogenic in mice when given in doses 1-10 times human dose; dexamethasone, hydrocortisone, and prednisolone were ocularly applied to both eyes of pregnant mice five times per day on days 10 through 13 of gestation; a significant increase in the incidence of cleft palate observed in fetuses of treated mice; there are no adequate well-controlled studies in pregnant women; prednisolone should be used during pregnancy only if potential benefit justifies potential risk to fetus
Lactation
Not known whether topical ophthalmic administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in breast milk; systemically administered corticosteroids appear in human milk and could suppress growth, interfere with endogenous corticosteroid production, or cause other untoward effects
Because of potential for serious adverse reactions in nursing infants from prednisolone, a decision should be made whether to discontinue nursing or to discontinue drug, taking into account importance of drug to mother
Interactions
Efficacy of Prednisolone may be reduced by phenobarb, phenytoin, rifampicin.
Corticoids may reduce the effects of:
diuretics, hypoglycaemics, anticholinesterases, salicylates.
Adverse Effects
Side effects of Prednisolone :
Acne, Adrenal suppression, Diabetes mellitus, Delayed wound healing, GI perforation, Glucose intolerance, Hepatomegaly, Hypokalemic alkalosis, Increased transaminases, Insomnia, Myopathy, Menstrual irregularity, Neuritis, Osteoporosis, Peptic ulcer, Perianal pruritus, Pituitary adrenal axis suppression, Pseudotumor cerebri (on withdrawal), Seizure, Psychosis, Ulcerative esophagitis, Urticaria, Vertigo, Weight gain
Potentially Fatal: Acute adrenal insufficiency precipitated by infection, trauma or surgery in patients on long-term therapy or following cessation of such therapy. CV collapse following rapid IV injection.
Mechanism of Action
Prednisolone decreases inflammation by inhibition of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability. It suppresses the immune system by reducing the activity and production of the lymphocytes and eosinophils.
Note
Predo 3mg/ml Syrup manufactured by Jazeera Pharmaceutical Industries. Its generic name is Prednisolone. Predo is availble in United Arab Emirates.
Farmaco UAE drug index information on Predo Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.
Some other brands of Prednisolone :
Tablets
Gupisone
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Julphar (Gulf Pharmaceutical Industries)
Tablets
Gupisone
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Julphar (Gulf Pharmaceutical Industries)
Tablets
Gupisone
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Julphar (Gulf Pharmaceutical Industries)