Solone Tablets

Prednisolone
5mg
FAWNS & McALLAN
Pack size 1000's
Dispensing mode POM
Source AUSTRALIA
AgentNEW MEDICAL CENTRE
Retail Price 64.00 AED

Solone Overview

Solone generic name is Prednisolone. Prednisolone is a steroid medication that is used to treat a wide variety of inflammatory and immune-mediated conditions, including allergic disorders, skin conditions, respiratory diseases, blood disorders, and certain types of cancer. It works by reducing inflammation and suppressing the immune system. Prednisolone is available in both oral and intravenous forms and can also be used as an eye drop or an inhaler. Prednisolone can cause serious side effects, especially if taken for a long time or at a high dose, such as weight gain, diabetes, osteoporosis, high blood pressure, cataracts, and increased risk of infections. It's important to take prednisolone exactly as prescribed by your doctor and to follow the recommended dosage schedule. Your doctor may need to monitor your blood sugar and bone density while you are taking this medication. It's also essential to inform your doctor if you are pregnant, breastfeeding or planning to become pregnant.

Indications

Solone Tablets is used for: Allergic and inflammatory disorders, Rheumatoid arthritis, Multiple sclerosis, Nephrotic syndrome, Joint inflammations, Idiopathic thrombocytopenic purpura, Moderate to severe asthma, Infantile spasms

Adult Dose

Oral Allergic and inflammatory disorders Adult: 5-60 mg daily in 2-4 divided doses. Maintenance: 2.5-15 mg daily. Withdrawal should be gradual after long-term therapy. Poorly controlled, moderate to severe asthma, COPD Adult: Patients with at least 2 exacerbations/yr requiring oral corticosteroids: 40-60 mg daily in 1-2 divided doses; usually given as a short course treatment over 10-14 days until symptom resolution and patient achieves a peak expiratory flow (PEF) of at least 80% of his or her personal best. Rheumatoid arthritis Adult: Initially, 5-7.5 mg daily, adjusted as necessary. Elderly: 5 mg daily. Multiple sclerosis Adult: 200 mg daily for 1 wk followed by 80 mg every other day for 1 mth. Bells Palsy 60 mg PO qDay for 5 days; then taper down by 10 mg daily for 5 days for total duration time of 10 days

Child Dose

Inflammation 0.1-2 mg/kg/day PO in single daily dose or divided q6-12hr; not to exceed 80 mg/day Acute Asthma 1-2 mg/kg/day in single daily dose or divided q12hr for 3-5 days Nephrotic Syndrome First 4 weeks: 60 mg/m²/day or 2 mg/kg/day PO divided q8hr until urine is protein free for 3 consecutive days; not to exceed 28 days; dose not to exceed 80 mg/day Subsequent 4 weeks: 40 mg/m² or 1-1.5 mg/kg PO every other day; not to exceed 80 mg/day Maintenance in frequent relapses: 0.5-1 mg/kg/dose PO every other day for 3-6 months Idiopathic thrombocytopenic purpura Child: 1-10 yr: 1-2 mg/kg daily (max: 14 days) or 4 mg/kg daily (max: 4 days).

Renal Dose

Administration

Should be taken with food.

Contra Indications

- Herpes simplex keratitis - Live vaccines - Systemic infections

Precautions

Patients with hypothyroidism, ulcerative colitis, cirrhosis, CHF, convulsive disorders, peptic ulcer, thrombophlebitis, elderly. DM, hypertension, psychological disturbances, osteoporosis; Adrenal suppression and infection. May cause irreversible growth retardation, glaucoma, corneal perforation. Pregnancy, lactation. Lactation: Excreted in breast milk; use caution

Pregnancy-Lactation

Pregnancy Prednisolone shown to be teratogenic in mice when given in doses 1-10 times human dose; dexamethasone, hydrocortisone, and prednisolone were ocularly applied to both eyes of pregnant mice five times per day on days 10 through 13 of gestation; a significant increase in the incidence of cleft palate observed in fetuses of treated mice; there are no adequate well-controlled studies in pregnant women; prednisolone should be used during pregnancy only if potential benefit justifies potential risk to fetus Lactation Not known whether topical ophthalmic administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in breast milk; systemically administered corticosteroids appear in human milk and could suppress growth, interfere with endogenous corticosteroid production, or cause other untoward effects Because of potential for serious adverse reactions in nursing infants from prednisolone, a decision should be made whether to discontinue nursing or to discontinue drug, taking into account importance of drug to mother

Interactions

Efficacy of Prednisolone may be reduced by phenobarb, phenytoin, rifampicin. Corticoids may reduce the effects of: diuretics, hypoglycaemics, anticholinesterases, salicylates.

Adverse Effects

Side effects of Prednisolone : Acne, Adrenal suppression, Diabetes mellitus, Delayed wound healing, GI perforation, Glucose intolerance, Hepatomegaly, Hypokalemic alkalosis, Increased transaminases, Insomnia, Myopathy, Menstrual irregularity, Neuritis, Osteoporosis, Peptic ulcer, Perianal pruritus, Pituitary adrenal axis suppression, Pseudotumor cerebri (on withdrawal), Seizure, Psychosis, Ulcerative esophagitis, Urticaria, Vertigo, Weight gain Potentially Fatal: Acute adrenal insufficiency precipitated by infection, trauma or surgery in patients on long-term therapy or following cessation of such therapy. CV collapse following rapid IV injection.

Mechanism of Action

Prednisolone decreases inflammation by inhibition of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability. It suppresses the immune system by reducing the activity and production of the lymphocytes and eosinophils.

Note

Solone 5mg Tablets manufactured by FAWNS & McALLAN. Its generic name is Prednisolone. Solone is availble in United Arab Emirates. Farmaco UAE drug index information on Solone Tablets is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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