Ziagen Solution (Oral)
Abacavir (as sulfate)
20mg/ml
Glaxo
| Pack size | 240ml Bottle |
|---|---|
| Dispensing mode | POM |
| Source | UK |
| Agent | AL BAKER TRADING EST. |
| Retail Price | 288.00 AED |
Indications
Ziagen Solution (Oral) is used for:
For the treatment of HIV-1 infection, in combination with other antiretroviral agents.
Oral
HIV infection
Adult Dose
Combined with other antiretrovirals:
300 mg bid or 600 mg once daily.
Child Dose
Child:
≥3 mth 14 to <20 kg: 150 mg bid or 300 mg once daily;
≥20 kg to <25 kg: 150 mg in the morning and 300 mg in the evening or 450 mg once daily;
≥25 kg: Same as adult dose.
Renal Dose
Not recommended.
Administration
May be taken with or without food.
Contra Indications
- HLA-B*57:01 allele positive patients
- Moderate to severe hepatic impairment.
- Lactation.
- Hypersensitivity to abacavir
Precautions
Hepatic Impairment: Mild (Child-Pugh score 5-6): 200 mg bid. Contraindicated in Moderate to severe Hepatic Impairment.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Abacavir (as sulfate) :
Fever, cough, rash, lethargy, malaise, dyspnoea, headache, GI disturbances, myalgia, particularly nausea, vomiting, diarrhoea and abdominal pain;
pancreatitis and elevated liver enzyme values, osteonecrosis, immune reconstitution syndrome, MI, lipodystrophy syndrome.
Rarely:
Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis.
Potentially Fatal:
Serious and fatal hypersensitivity reactions w/ multiple organ involvement, lactic acidosis and severe hepatomegaly w/ steatosis.
Mechanism of Action
Abacavir is a carbocyclic synthetic nucleoside analogue and an antiviral agent. Intracellularly, abacavir is converted by cellular enzymes to the active metabolite carbovir triphosphate, an analogue of deoxyguanosine-5'-triphosphate (dGTP). Carbovir triphosphate inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA. Viral DNA growth is terminated because the incorporated nucleotide lacks a 3'-OH group, which is needed to form the 5' to 3' phosphodiester linkage essential for DNA chain elongation.
Note
Ziagen 20mg/ml Solution (Oral) manufactured by Glaxo. Its generic name is Abacavir (as sulfate). Ziagen is availble in United Arab Emirates.
Farmaco UAE drug index information on Ziagen Solution (Oral) is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.