Ziagen Tablets / Film-coated
Abacavir (as sulfate)
300mg
GLAXOSMITHKLINE PHARMACEUTICAL S.A.
| Pack size | 60's (10's Blister x 6) |
|---|---|
| Dispensing mode | POM |
| Source | POLAND |
| Agent | AL BAKER TRADING EST. |
| Retail Price | 1320.00 AED |
Indications
Ziagen Tablets / Film-coated is used for:
For the treatment of HIV-1 infection, in combination with other antiretroviral agents.
Oral
HIV infection
Adult Dose
Combined with other antiretrovirals:
300 mg bid or 600 mg once daily.
Child Dose
Child:
≥3 mth 14 to <20 kg: 150 mg bid or 300 mg once daily;
≥20 kg to <25 kg: 150 mg in the morning and 300 mg in the evening or 450 mg once daily;
≥25 kg: Same as adult dose.
Renal Dose
Not recommended.
Administration
May be taken with or without food.
Contra Indications
- HLA-B*57:01 allele positive patients
- Moderate to severe hepatic impairment.
- Lactation.
- Hypersensitivity to abacavir
Precautions
Hepatic Impairment: Mild (Child-Pugh score 5-6): 200 mg bid. Contraindicated in Moderate to severe Hepatic Impairment.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Abacavir (as sulfate) :
Fever, cough, rash, lethargy, malaise, dyspnoea, headache, GI disturbances, myalgia, particularly nausea, vomiting, diarrhoea and abdominal pain;
pancreatitis and elevated liver enzyme values, osteonecrosis, immune reconstitution syndrome, MI, lipodystrophy syndrome.
Rarely:
Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis.
Potentially Fatal:
Serious and fatal hypersensitivity reactions w/ multiple organ involvement, lactic acidosis and severe hepatomegaly w/ steatosis.
Mechanism of Action
Abacavir is a carbocyclic synthetic nucleoside analogue and an antiviral agent. Intracellularly, abacavir is converted by cellular enzymes to the active metabolite carbovir triphosphate, an analogue of deoxyguanosine-5'-triphosphate (dGTP). Carbovir triphosphate inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA. Viral DNA growth is terminated because the incorporated nucleotide lacks a 3'-OH group, which is needed to form the 5' to 3' phosphodiester linkage essential for DNA chain elongation.
Note
Ziagen 300mg Tablets / Film-coated manufactured by GLAXOSMITHKLINE PHARMACEUTICAL S.A.. Its generic name is Abacavir (as sulfate). Ziagen is availble in United Arab Emirates.
Farmaco UAE drug index information on Ziagen Tablets / Film-coated is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.