Zovirax 5% Cream (Cold Sore)

Acyclovir 5% Topical
50mg/g
GLAXO WELLCOME OPERATIONS
Pack size 2g Pump Pack
Dispensing mode POM
Source UK
AgentAL BAKER TRADING EST.
Retail Price 30.00 AED

Available as:

50mg/g - Cream

Indications

Zovirax 5% Cream (Cold Sore) is used for: Herpes virus infections of skin

Adult Dose

As 5% oint/cream: Apply to the affected skin 5-6 times/day for 5-10 days.

Child Dose

Renal Dose

Administration

Contra Indications

Hypersensitivity.

Precautions

Renal impairment. Pregnancy, lactation. Neurological abnormalities with significant hypoxia, serious hepatic or electrolyte abnormalities. Maintain adequate hydration. Lactation: Excretion in milk unknown; systemic exposure is minimal after topical application.

Pregnancy-Lactation

Pregnancy category: B Lactation: Excretion in milk unknown; systemic exposure is minimal after topical application

Interactions

Probenecid, cimetidine and mycophenolate mofetil may increase the plasma concentration of aciclovir. Increased nephrotoxic effects w/ drugs that affect renal physiology (e.g. ciclosporin, tacrolimus).

Adverse Effects

Side effects of Acyclovir 5% Topical : >10% Burning/stinging (30%) 1-10% Pruritus (4%) <1% Dry lips (<1%), Rash (0.3%) Frequency Not Defined Angioedema, Vulvitis

Mechanism of Action

Activity against HSV types I and II and varicella-zoster virus is due to intracellular conversion of aciclovir to the monophosphate by viral thymidine kinase with subsequent conversion to the diphosphate and active triphosphate by cellular enzymes. This active form inhibits viral DNA synthesis and replication by interfering with viral DNA polymerase enzyme and being incorporated into viral DNA.

Note

Zovirax 5% 50mg/g Cream (Cold Sore) manufactured by GLAXO WELLCOME OPERATIONS. Its generic name is Acyclovir 5% Topical. Zovirax 5% is availble in United Arab Emirates. Farmaco UAE drug index information on Zovirax 5% Cream (Cold Sore) is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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