Abacavir (as sulphate), Lamivudine, Zidovudine

Indications

Abacavir (as sulphate), Lamivudine, Zidovudine is used for: ABACAVIR
For the treatment of HIV-1 infection, in combination with other antiretroviral agents. LAMIVUDINE
For the treatment of HIV infection and chronic hepatitis B (HBV). ZIDOVUDINE
Used in combination with other antiretroviral agents for the treatment of human immunovirus (HIV) infections.

Adult Dose

Child Dose

Renal Dose

Administration

Contra Indications

Precautions

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Abacavir (as sulphate), Lamivudine, Zidovudine :

Mechanism of Action

ABACAVIR
Abacavir is a carbocyclic synthetic nucleoside analogue and an antiviral agent. Intracellularly, abacavir is converted by cellular enzymes to the active metabolite carbovir triphosphate, an analogue of deoxyguanosine-5'-triphosphate (dGTP). Carbovir triphosphate inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA. Viral DNA growth is terminated because the incorporated nucleotide lacks a 3'-OH group, which is needed to form the 5' to 3' phosphodiester linkage essential for DNA chain elongation. LAMIVUDINE
Lamivudine is a synthetic nucleoside analogue and is phosphorylated intracellularly to its active 5'-triphosphate metabolite, lamivudine triphosphate (L-TP). This nucleoside analogue is incorporated into viral DNA by HIV reverse transcriptase and HBV polymerase, resulting in DNA chain termination. ZIDOVUDINE
Zidovudine, a structural analog of thymidine, is a prodrug that must be phosphorylated to its active 5'-triphosphate metabolite, zidovudine triphosphate (ZDV-TP). It inhibits the activity of HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleotide analogue. It competes with the natural substrate dGTP and incorporates itself into viral DNA. It is also a weak inhibitor of cellular DNA polymerase a and ?.