Bacitracin zinc, Neomycin sulfate
Indications
Bacitracin zinc, Neomycin sulfate is used for:
BACITRACIN
For the treatment of infants with pneumonia and empyema caused by staphylococci shown to be susceptible to the drug. Also used in ointment form for topical treatment of a variety of localized skin and eye infections, as well as for the prevention of wound infections. Used against gram positive bacteria. Bacitracin is also used as an inhibitor of proteases and other enzymes. However, specific activity of bactracin's inhibition of protein disulfide isomerase has been called into question
NEOMYCIN
Topical uses include treatment for superficial eye infections caused by susceptible bacteria (used in combination with other antiinfectives), treatment of otitis externa caused by susceptible bacteria, treatment or prevention of bacterial infections in skin lesions, and use as a continuous short-term irrigant or rinse to prevent bacteriuria and gram negative rod bacteremia in abacteriuric patients with indwelling catheters. May be used orally to treat hepatic encephalopathy, as a perioperative prophylactic agent, and as an adjunct to fluid and electrolyte replacement in the treatment of diarrhea caused to enteropathogenic e. Coli (epec)
For the treatment of infants with pneumonia and empyema caused by staphylococci shown to be susceptible to the drug. Also used in ointment form for topical treatment of a variety of localized skin and eye infections, as well as for the prevention of wound infections. Used against gram positive bacteria. Bacitracin is also used as an inhibitor of proteases and other enzymes. However, specific activity of bactracin's inhibition of protein disulfide isomerase has been called into question
NEOMYCIN
Topical uses include treatment for superficial eye infections caused by susceptible bacteria (used in combination with other antiinfectives), treatment of otitis externa caused by susceptible bacteria, treatment or prevention of bacterial infections in skin lesions, and use as a continuous short-term irrigant or rinse to prevent bacteriuria and gram negative rod bacteremia in abacteriuric patients with indwelling catheters. May be used orally to treat hepatic encephalopathy, as a perioperative prophylactic agent, and as an adjunct to fluid and electrolyte replacement in the treatment of diarrhea caused to enteropathogenic e. Coli (epec)
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Bacitracin zinc, Neomycin sulfate :
Mechanism of Action
BACITRACIN
Bacitracin intereferes with the dephosphorylation of the 55-carbon, biphosphate lipid transport molecule c55-isoprenyl pyrophosphate (undecaprenyl pyrophosphate), which carries the building blocks of the peptidoglycan bacterial cell wall outside the inner membrane for construction. Bacitracin binds divalent transition metal ions (mn(ii), co(ii), ni(ii), cu(ii), and zn(ii)) which binds and oxidatively cleave dna
NEOMYCIN
Aminoglycosides like neomycin "irreversibly" bind to specific 30s-subunit proteins and 16s rrna. Specifically neomycin binds to four nucleotides of 16s rrna and a single amino acid of protein s12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16s rrna of 30s subunit. This region interacts with the wobble base in the anticodon of trna. This leads to interference with the initiation complex, misreading of mrna so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes
Bacitracin intereferes with the dephosphorylation of the 55-carbon, biphosphate lipid transport molecule c55-isoprenyl pyrophosphate (undecaprenyl pyrophosphate), which carries the building blocks of the peptidoglycan bacterial cell wall outside the inner membrane for construction. Bacitracin binds divalent transition metal ions (mn(ii), co(ii), ni(ii), cu(ii), and zn(ii)) which binds and oxidatively cleave dna
NEOMYCIN
Aminoglycosides like neomycin "irreversibly" bind to specific 30s-subunit proteins and 16s rrna. Specifically neomycin binds to four nucleotides of 16s rrna and a single amino acid of protein s12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16s rrna of 30s subunit. This region interacts with the wobble base in the anticodon of trna. This leads to interference with the initiation complex, misreading of mrna so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes