Brinzolamide 1% Eye prep

Indications

Brinzolamide 1% Eye prep is used for: Open-angle glaucoma , ocular hypertension

Adult Dose

Adult: Ophth Open-angle glaucoma; Ocular HTN As 1% susp: Instill 1 drop 2-3 times/day.

Child Dose

Renal Dose

Administration

May be used concomitantly with other topical ophthalmic drug products to lower intraocular pressure; if more than one topical ophthalmic drug being used, administer at least ten min apart

Contra Indications

Brinzolamide 1% ophthalmic suspension is contraindicated in patients who are hypersensitive to any component of this product.

Precautions

Hepatic and renal impairment; pregnancy. Efficacy has not been established in angle-closure glaucoma. Ensure an interval of at least 10 minutes between admin of different ophthalmic solutions. Lactation: Not known if distributed in breast milk; not recommedned (discontinue drug or do not nurse)

Pregnancy-Lactation

Pregnancy Category: C Lactation: Not known if distributed in breast milk; not recommedned (discontinue drug or do not nurse)

Interactions

Brinzolamide: Concurrent use w/ oral carbonic anhydrase inhibitors may lead to additive systemic effects. Concurrent use w/ high-dose salicylates may lead to toxicity.

Adverse Effects

Side effects of Brinzolamide 1% Eye prep : 1-10% Blurred vision (5-10%), Dysgeusia (5-10%), Blepharitis (1-5%), Dermatitis (1-5%), Dry eye (1-5%), Foreign body sensation (1-5%), Headache (1-5%), Hyperemia (1-5%), Ocular discharge (1-5%), Ocular discomfort (1-5%), Ocular keratitis (1-5%), Ocular pain (1-5%), Ocular pruritus (1-5%), Rhinitis (1-5%) <1% Allergic reactions, Alopecia, Chest pain, Conjunctivitis, Diarrhea, Diplopia, Dizziness, Dry mouth, Dyspnea, Dyspepsia, Eye fatigue, Hypertonia, Keratoconjunctivitis, Keratopathy, Kidney pain, Lid margin crusting or sticky sensation, Nausea, Pharyngitis, Tearing, Urticaria

Mechanism of Action

Brinzolamide is a carbonic anhydrase inhibitor that decreases secretion of aqueous humor thus reducing intraocular pressure.