Cetrorelix

Indications

Cetrorelix is used for: Assisted reproductive technologies, In-vitro fertilization

Adult Dose

Subcutaneous Assisted reproductive technologies Adult: As acetate: equiv to 0.25 mg cetrorelix either in the morning beginning on the day 5 or 6 of ovarian stimulation or in the evening beginning on day 5, and continued until ovulation induction.

Child Dose

Renal Dose

Severe renal impairment: Contraindicated

Administration

Contra Indications

Hypersensitivity. Moderate to severe renal or hepatic impairment. Women with severe allergic conditions. Pregnancy and lactation;

Precautions

Women with active allergic conditions or a history of allergies; childn; elderly >65 yrs Lactation: Excretion in milk unknown/contraindicated

Pregnancy-Lactation

Pregnancy Category: X Lactation: Excretion in milk unknown/contraindicated

Interactions

In vitro investigations have shown that interactions are unlikely with medications that are metabolised by cytochrome P-450 or glucuronised or conjugated in some other way. However, the possibility of interactions with commonly used medicinal products can not entirely be excluded.

Adverse Effects

Side effects of Cetrorelix : 1-10% Ovarian hyperstimulation syndrome (4%), Nausea (1%), Hepatic enzyme elevation (1-2%), Headache (1%) <1% Erythema at injection site, Itching, Pruritus, Swelling, Redness, Hypotension, Rash, Cough

Mechanism of Action

Cetrorelix, a synthetic decapeptide analog of naturally occurring gonadorelin, is a gonadorelin antagonist. It competitively blocks gonadorelin receptors on the anterior piyuitary gonadotroph and the subsequent transduction pathway, inducing a rapid, reversible suppression of gonadotrophin secretion.