Chlorpheniramine + Phenylephrine

Indications

Chlorpheniramine + Phenylephrine is used for: Nasal Congestion, Sneezing, Common Cold, Hay Fever, Allergic Rhinitis

Adult Dose

Nasal Congestion or Sneezing Due to Common Cold, Hay Fever, Allergic Rhinitis 1 tablet PO q4hr; not to exceed 6 tab/24h

Child Dose

Nasal Congestion or Sneezing Due to Common Cold, Hay Fever, Allergic Rhinitis >12 Years Old 1 tablet PO q4hr; not to exceed 6 tab/24 hr

Renal Dose

Administration

Contra Indications

Contraindicated in documented hypersensitivity; asthma attacks, narrow-angle glaucoma, symptomatic prostate hypertrophy, bladder-neck obstruction, and stenosing peptic ulcer

Precautions

Caution in elderly patients, hyperthyroidism, myocardial disease, bradycardia, partial heart block or severe arteriosclerosis when administering phenylephrine; in hypovolemia, phenylephrine use is not a substitute for replacement of blood, fluids and electrolytes, and plasma (promptly restore with loss); dilute IV and administer via large vein; extravasation precautions required Chlorpheniramine may cause significant confusional symptoms; not for administration to premature or full-term neonates Lactation: excretion in milk unknown/contraindicated

Pregnancy-Lactation

Pregnancy Category: C Lactation: excretion in milk unknown/contraindicated

Interactions

Adverse Effects

Side effects of Chlorpheniramine + Phenylephrine : Hypertension, Hypotension, Palpitations, Reflex tachycardia, Severe peripheral and visceral vasoconstriction, Tachycardia, Confusion, Depression, Distress, Dizziness, Excitability, Euphoria, Fatigue, Headache, Insomnia, Irritability, Restlessness, Sedation, Tremor, Anorexia, Agranulocytosis, Hemolytic anemia, Thrombocytopenia, Thickening of bronchial secretions, Wheezing

Mechanism of Action

Chlorpheniramine blocks muscle responses in histamine and acts as an antagonism of the constrictor effects of histamine on respiratory smooth muscle. Phenylephrine is a vasoconstrictor and a decongestant that relieves symptoms resulting from irritation of upper respiratory tract tissue. It shrinks swollen mucous membranes, reduces nasal congestion and tissue hyperemia.