Clindamycin 2% Vaginal prep

Indications

Clindamycin 2% Vaginal prep is used for: Bacterial vaginosis

Adult Dose

Bacterial Vaginosis Vaginal cream: 1 full applicator inserted (approximately 5 gram) intravaginally at bedtime for 3 days in nonpregnant patients and for 7 days in pregnant patients

Child Dose

<12 years old Safety and efficacy not established

Renal Dose

Administration

Contra Indications

Hypersensitivity.Clindamycin cream is also contraindicated in individuals with a history of regional enteritis, ulcerative colitis, or a history of \"antibiotic-associated\" colitis.

Precautions

The patient should be instructed not to engage in vaginal intercourse, or use other vaginal products during treatment with this product. This cream contains mineral oil that may weaken latex or rubber products such as condoms or vaginal contraceptive diaphragms. Therefore, use of such products within 72 hours following treatment with Clindacin cream is not recommended. Lactation: Excretion in milk unknown; use with caution

Pregnancy-Lactation

Interactions

May enhance the action of neuromuscular blocking agents (e.g. atracurium). May antagonise the effects of parasympathomimetics. May competitively inhibit the effects of macrolides, ketolides, streptogramins, linezolid and chloramphenicol. Increased coagulation tests (prothrombin time/INR) and/or bleeding w/ vit K antagonists (e.g. warfarin, acenocoumarol, fluindione).

Adverse Effects

Side effects of Clindamycin 2% Vaginal prep : Genital tract: vaginitis, vulvo-vaginal irritation Central nervous system: dizziness, headache, vertigo. Gastro-intestinal: heartburn, nausea, vomiting, diarrhea, constipation, abdominal pain. Dermatological: rash, exanthema. Hypersensitivity: urticaria.

Mechanism of Action

Clindamycin inhibits protein synthesis by reversibly binding to the 50S subunit of the ribosomal thus blocking the transpeptidation or translocation reactions of susceptible organisms resulting to stunted cell growth.