Dextropropoxyphene HCl
Indications
Dextropropoxyphene HCl is used for:
For the relief of mild to moderate pain
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Dextropropoxyphene HCl :
Mechanism of Action
Propoxyphene acts as a weak agonist at op1, op2, and op3 opiate receptors within the central nervous system (cns). Propoxyphene primarily affects op3 receptors, which are coupled with g-protein receptors and function as modulators, both positive and negative, of synaptic transmission via g-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of gtp for gdp on the g-protein complex. As the effector system is adenylate cyclase and camp located at the inner surface of the plasma membrane, opioids decrease intracellular camp by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance p, gaba, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as propoxyphene also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close n-type voltage-operated calcium channels (op2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (op3 and op1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability