Estramustine Phosphate (as phosphate sodium monohydrate )
Indications
Estramustine Phosphate (as phosphate sodium monohydrate ) is used for:
For the palliative treatment of patients with metastatic and/or progressive carcinoma of the prostate
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Estramustine Phosphate (as phosphate sodium monohydrate ) :
Mechanism of Action
Estramustine is a derivative of estradiol with a nitrogen mustard moiety. This gives it alkylating properties. In vivo, the nitrogen mustard component is active and can alklyate DNA and other cellular components (such as tubulin components) of rapidly dividing cells. This causes DNA strandbreaks or misscoding events. This leads to apoptosis and cell death. Also, due to the drugs estrogen component, it can bind more selectively to active estrogen receptors.