Itopride

Indications

Itopride is used for: Functional dyspepsia, non-ulcer dyspepsia (chronic gastritis) i.e. sensation of bloating, early satiety, upper abdominal pain or discomfort, anorexia, heartburn, nausea and vomiting

Adult Dose

ADULT, by mouth, 50 mg 3 times daily. Take at least 1 hour before meals ELDERLY: May reduce dose

Child Dose

Renal Dose

Administration

For Oral use

Contra Indications

Hypersensitivity to Itopride or any of the excipients. Avoid use in conditions where increase in GI motility could be harmful e.g., GI hemorrhage, mechanical obstruction or perforation

Precautions

Itopride enhances the action of acetylcholine and may produce cholinergic side effects Elderly Pregnancy; Breastfeeding

Pregnancy-Lactation

Recommendations on the use of Itopride in Pregnancy & Lactation: There are no adequate and well-controlled studies in pregnant women. There are no known effects of Itopride hydrochloride on labour or delivery. Itopride is secreted in breastmilk and has potential for adverse effect in the nursing infants in animal studies. Therefore, itopride hydrochloride should not be used during pregnancy and lactation unless the benefits outweigh the potential risks and is advisable that breastfeeding is discontinued during treatment (Abbott, n.d.). References: 1. Abbott. (n.d.). Ganaton (itopride hydrochloride). Retrieved 13 November 2020, from https://www.mims.com/malaysia/drug/info/ganaton?type=full

Interactions

Due to its gastrokinetic effects, it may influence the absorption of co-administered oral drugs esp. drugs with a narrow therapeutic index, sustained-release or enteric-coated formulations. Anticholinergic drugs may antagonize some of its effects

Adverse Effects

Side effects of Itopride : Diarrhoea, constipation, abdominal pain, increased saliva and nausea; dizziness, headache and tremor; rash, redness and itching; jaundice, leukopenia and thrombocytoopenia; anaphylactoid reaction; increased prolactin level and gynaecomastia

Mechanism of Action