Mecobalamin
Indications
Mecobalamin is used for:
Megaloblastic anaemia, Peripheral neuropathies
Adult Dose
Oral
Peripheral neuropathies
Adult: 1500 mcg/day in 3 divided doses.
Parenteral
Peripheral neuropathies
Adult: 500 mcg daily IM/IV 3 times/wk.
Megaloblastic anaemia caused by vitamin B12 deficiency
Adult: 500 mcg daily IM/IV 3 times/wk.
Maintenance dose: After about 2 mth of therapy, reduce dose to single admin of 500 mcg every 1-3 mth.
Child Dose
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity to any component of this product.
Precautions
The medicine should not be used for months if there is no response at all after its use for a certain period of time.
Pregnancy-Lactation
Interactions
Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicine. Reduced serum concentrations with oral contraceptives. Reduced effects in anaemia with parenteral chloramphenicol.
Adverse Effects
Side effects of Mecobalamin :
Oral: Anorexia, nausea, vomiting and diarrhoea. Parenteral: Rash, headache, hot sensation, diaphoresis and pain/induration at IM inj site.
Potentially Fatal: Anaphylactoid reactions (parenteral).
Mechanism of Action
Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.