Meprobamate, Oxyphencyclimine HCl
Indications
Meprobamate, Oxyphencyclimine HCl is used for:
MEPROBAMATE
For the management of anxiety disorders or for the short-term relief of the symptoms of anxiety
OXYPHENCYCLIMINE
For the treatment of peptic ulcer disease and the relief of smooth muscle spasms in gastrointestinal disorders
For the management of anxiety disorders or for the short-term relief of the symptoms of anxiety
OXYPHENCYCLIMINE
For the treatment of peptic ulcer disease and the relief of smooth muscle spasms in gastrointestinal disorders
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Meprobamate, Oxyphencyclimine HCl :
Mechanism of Action
MEPROBAMATE
Meprobamate's mechanism of action is not known. It has been shown in animal studies to have effects at multiple sites in the central nervous system, including the thalamus and limbic system. Meprobamate binds to gabaa receptors which interrupt neuronal communication in the reticular formation and spinal cord, causing sedation and altered perception of pain
OXYPHENCYCLIMINE
Oxyphencyclimine binds the muscarinic acetylcholine receptor. It may block all three types of muscarinic receptors including m-1 receptors in the cns and ganglia, m-2 receptors in the heart (vagus) and m-3 receptors at the parasympathetic nej system. The muscarinic acetylcholine receptors mediate various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of g proteins. Oxphencyclimine inhibits vagally mediated reflexes by antagonizing the action of acetylcholine. This in turn reduces the secretion of gastric acids in the stomach
Meprobamate's mechanism of action is not known. It has been shown in animal studies to have effects at multiple sites in the central nervous system, including the thalamus and limbic system. Meprobamate binds to gabaa receptors which interrupt neuronal communication in the reticular formation and spinal cord, causing sedation and altered perception of pain
OXYPHENCYCLIMINE
Oxyphencyclimine binds the muscarinic acetylcholine receptor. It may block all three types of muscarinic receptors including m-1 receptors in the cns and ganglia, m-2 receptors in the heart (vagus) and m-3 receptors at the parasympathetic nej system. The muscarinic acetylcholine receptors mediate various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of g proteins. Oxphencyclimine inhibits vagally mediated reflexes by antagonizing the action of acetylcholine. This in turn reduces the secretion of gastric acids in the stomach