Pentosan Polysulphate Sodium

Indications

Pentosan Polysulphate Sodium is used for: Interstitial cystitis, Nocturia, Painful bladder syndrome, Dyspareunia

Adult Dose

Oral Interstitial cystitis Adult: 100 mg tid.

Child Dose

Renal Dose

Administration

Should be taken on an empty stomach. Take at least 1 hr before or 2 hr after meals.

Contra Indications

Patients who are haemorrhaging. Serious renal or hepatic impairment. Not to be given via IM inj.

Precautions

Patients with spleen disorders, hepatic or renal impairment. Monitor platelet counts during treatment. To discontinue treatment if thrombocytopenia occurs. Caution when used in patients with haemorrhagic blood disorders, thrombocytopenia, peptic ulcer disease, cerebrovascular disorders, bacterial endocarditis, severe hypertension or oesophageal varices. Recent surgery at sites where haemorrhage would be an especial risk. Safety not established in children <16 yr. Patients should be monitored every 3 mth; risks and benefits after 6 mth of treatment not known. Pregnancy; lactation. Lactation: not known if excreted in breast milk, use caution

Pregnancy-Lactation

Pregnancy Category: B Lactation: not known if excreted in breast milk, use caution

Interactions

Increased risk of bleeding when used with oral anticoagulants or drugs that affect platelet function. Concurrent admin with glyceryl trinitrate via IV route may reduce the efficacy of pentosan.

Adverse Effects

Side effects of Pentosan Polysulphate Sodium : 1-10% Alopecia (4%), Diarrhea (4%), Nausea (4%), Headache (3%), Abdominal pain (2%), Indigestion (2%)

Mechanism of Action

Pentosan polysulfate sodium is a heparinoid with anticoagulant and fibrinolytic properties; it may also have hypolipidaemic and anti-inflammatory effects. It is used in thromboembolic disorders, although its anticoagulant effect is less than that of heparin. It is also used in the management of interstitial cystitis and has been tried in a number of other conditions, including variant Creutzfeldt-Jakob disease.