Phospholipids
Indications
Phospholipids is used for:
Resp distress syndrome (RDS) in premature infants.
Adult Dose
Child Dose
Prevention in premature infant <1250 g birthwt or w/ evidence of surfactant deficiency
Preferably w/in 15 mins of birth.
Rescue Preferably by 8 hr of age.
4 mL/kg birth wt(100 mg of phospholipids/kg birth wt) intratracheally up to 4 doses in 1st 48 hr.
Doses should not be given more frequently than 6 hrly. To be administered as soon as possible.
Renal Dose
Administration
Contra Indications
None known.
Precautions
Infants <600 g birth wt. For intratracheal use only.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Phospholipids :
Transient bradycardia. O2 desaturation, endotracheal tube reflux & blockage, pallor, vasoconstriction, hypotension, HTN, hypocarbia, hypercarbia & apnea.
Mechanism of Action
Natural bovine pulmonary surfactant; replaces deficient endogenous lung surfactant in neonates with respiratory distress syndrome.
Surfactant prevents the alveoli from collapsing during expiration by lowering surface tension between alveolar surfaces and air.