Anafranil Tablets

Clomipramine Hydrochloride
10mg
Novartis Pharma AG
Pack size 30's (10's Blister x 3)
Dispensing mode POM
Source SWITZERLAND
AgentCITY MEDICAL STORE
Retail Price 15.00 AED

Indications

Anafranil Tablets is used for: Depression, Panic disorder, Obsessive compulsive disorder, Cataplexy, Narcolepsy, Phobias, Premature ejaculation, Enuresis, Trichotillomania

Adult Dose

Oral Adjunct for cataplexy associated with narcolepsy Adult: Initially, 10 mg daily gradually increased to 10-75 mg daily. Elderly: Dose reduction may be needed. Obsessive compulsive disorder; Panic disorder; Phobias Adult: Initially, 25 mg daily, gradually increased to 100-150 mg daily over 2 wk. Max: 250 mg daily. Elderly: Initially, 10 mg daily. Depression Adult: Initially, 10 mg daily; may increase gradually to 30-150 mg daily if needed. Up to 250 mg daily or more may be required in more severe cases. Elderly: Initially, 10 mg daily; may increase gradually over 10 days to 30-75 mg daily. Max Dosage: 100-150 mg daily.

Child Dose

Obsessive-Compulsive Disorder <10 years: Safety and efficacy not established >10 years: 25 mg PO qDay initially Gradually increase to maximum 3 mg/kg/day or 100 mg/day, whichever is less May further increase to maximum 3 mg/kg/day or 200 mg/day, whichever is less; may give as single dose qHS once tolerated

Renal Dose

Administration

Should be taken with food.

Contra Indications

Hypersensitivity. Concomitant use of MAOIs; recovery phase following MI, heartblock or other arrhythmias; mania; childn.

Precautions

Cardiovascular insufficiency; narrow-angle glaucoma; urinary retention; history of epilepsy; renal or hepatic dysfunction; electroconvulsive therapy; hypotension; hyperthyroidism or concomitant treatment with thyroid preparations; suicidal tendencies; surgery; pregnancy and lactation; tasks requiring mental alertness; elderly; avoid abrupt withdrawal. Lactation: distributed in breast milk, do not nurse (AAP states effect on nursing infants is unknown but may be of concern)

Pregnancy-Lactation

Pregnancy Category: C Lactation: distributed in breast milk, do not nurse (AAP states effect on nursing infants is unknown but may be of concern)

Interactions

Barbiturates increase metabolism of tricyclic antidepressants; conversely cimetidine, guanethidine, haloperidol and phenothiazines block the tricyclic metabolism. CNS effects of alcohol enhanced. Potentially Fatal: If clomipramine is to be substituted for MAOIs, at least 3 wk should elapse after discontinuing MAOIs. Risk of hypertension and arrhythmias if co-administered with adrenaline and noradrenaline.

Adverse Effects

Side effects of Clomipramine Hydrochloride : >10% Xerostomia (84%), Headache (50-55%), Constipation (47%), Ejaculation failure (42%), Fatigue (35-40%), Nausea (30-35%), Impotence (20-25%), Weight gain (18%) 1-10% Weight loss (5%), Hepatotoxicity (1-3%) Frequency Not Defined Common, Dizziness, mainia, somnolence, tremor, Dyspepsia, Blurred vision, Urinary retention, Orgasm incapacity, libido change Potentially Fatal: Death, rare (except in patients with preexisting significant heart block and patients on MAOI therapy). Induction of mania in individuals with underlying manic-depressive illness or worsening of psychoses in already psychotic individuals.

Mechanism of Action

Clomipramine is a potent inhibitor of serotonin re-uptake in the brain. Significant antagonism at cholinergic and ?1-receptors. Weak antagonism at dopamine receptors. It has also antidepressant, sedative and anticholinergic effects.

Note

Anafranil 10mg Tablets manufactured by Novartis Pharma AG. Its generic name is Clomipramine Hydrochloride. Anafranil is availble in United Arab Emirates. Farmaco UAE drug index information on Anafranil Tablets is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Clomipramine Hydrochloride :