Anafranil S.R Tablets / Divitabs
Clomipramine Hydrochloride
75mg
Novartis Pharma AG
| Pack size | 20's (10's Blister x 2) |
|---|---|
| Dispensing mode | POM |
| Source | SWITZERLAND |
| Agent | CITY MEDICAL STORE |
| Retail Price | 54.00 AED |
Available as:
Indications
Anafranil S.R Tablets / Divitabs is used for:
Depression, Panic disorder, Obsessive compulsive disorder, Cataplexy, Narcolepsy, Phobias, Premature ejaculation, Enuresis, Trichotillomania
Adult Dose
Oral
Adjunct for cataplexy associated with narcolepsy
Adult: Initially, 10 mg daily gradually increased to 10-75 mg daily.
Elderly: Dose reduction may be needed.
Obsessive compulsive disorder; Panic disorder; Phobias
Adult: Initially, 25 mg daily, gradually increased to 100-150 mg daily over 2 wk. Max: 250 mg daily.
Elderly: Initially, 10 mg daily.
Depression
Adult: Initially, 10 mg daily; may increase gradually to 30-150 mg daily if needed. Up to 250 mg daily or more may be required in more severe cases.
Elderly: Initially, 10 mg daily; may increase gradually over 10 days to 30-75 mg daily.
Max Dosage: 100-150 mg daily.
Child Dose
Obsessive-Compulsive Disorder
<10 years: Safety and efficacy not established
>10 years: 25 mg PO qDay initially
Gradually increase to maximum 3 mg/kg/day or 100 mg/day, whichever is less
May further increase to maximum 3 mg/kg/day or 200 mg/day, whichever is less; may give as single dose qHS once tolerated
Renal Dose
Administration
Should be taken with food.
Contra Indications
Hypersensitivity. Concomitant use of MAOIs; recovery phase following MI, heartblock or other arrhythmias; mania; childn.
Precautions
Cardiovascular insufficiency; narrow-angle glaucoma; urinary retention; history of epilepsy; renal or hepatic dysfunction; electroconvulsive therapy; hypotension; hyperthyroidism or concomitant treatment with thyroid preparations; suicidal tendencies; surgery; pregnancy and lactation; tasks requiring mental alertness; elderly; avoid abrupt withdrawal.
Lactation: distributed in breast milk, do not nurse (AAP states effect on nursing infants is unknown but may be of concern)
Pregnancy-Lactation
Pregnancy Category: C
Lactation: distributed in breast milk, do not nurse (AAP states effect on nursing infants is unknown but may be of concern)
Interactions
Barbiturates increase metabolism of tricyclic antidepressants; conversely cimetidine, guanethidine, haloperidol and phenothiazines block the tricyclic metabolism. CNS effects of alcohol enhanced.
Potentially Fatal: If clomipramine is to be substituted for MAOIs, at least 3 wk should elapse after discontinuing MAOIs. Risk of hypertension and arrhythmias if co-administered with adrenaline and noradrenaline.
Adverse Effects
Side effects of Clomipramine Hydrochloride :
>10%
Xerostomia (84%), Headache (50-55%), Constipation (47%), Ejaculation failure (42%), Fatigue (35-40%), Nausea (30-35%), Impotence (20-25%), Weight gain (18%)
1-10%
Weight loss (5%), Hepatotoxicity (1-3%)
Frequency Not Defined
Common, Dizziness, mainia, somnolence, tremor, Dyspepsia, Blurred vision, Urinary retention, Orgasm incapacity, libido change
Potentially Fatal: Death, rare (except in patients with preexisting significant heart block and patients on MAOI therapy). Induction of mania in individuals with underlying manic-depressive illness or worsening of psychoses in already psychotic individuals.
Mechanism of Action
Clomipramine is a potent inhibitor of serotonin re-uptake in the brain. Significant antagonism at cholinergic and ?1-receptors. Weak antagonism at dopamine receptors. It has also antidepressant, sedative and anticholinergic effects.
Note
Anafranil S.R 75mg Tablets / Divitabs manufactured by Novartis Pharma AG. Its generic name is Clomipramine Hydrochloride. Anafranil S.R is availble in United Arab Emirates.
Farmaco UAE drug index information on Anafranil S.R Tablets / Divitabs is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.