Anafranil Tablets
Clomipramine Hydrochloride
25mg
Novartis Pharma AG
| Pack size | 30's (10's Blister x 3) |
|---|---|
| Dispensing mode | POM |
| Source | SWITZERLAND |
| Agent | CITY MEDICAL STORE |
| Retail Price | 21.50 AED |
Available as:
Indications
Anafranil Tablets is used for:
Depression, Panic disorder, Obsessive compulsive disorder, Cataplexy, Narcolepsy, Phobias, Premature ejaculation, Enuresis, Trichotillomania
Adult Dose
Oral
Adjunct for cataplexy associated with narcolepsy
Adult: Initially, 10 mg daily gradually increased to 10-75 mg daily.
Elderly: Dose reduction may be needed.
Obsessive compulsive disorder; Panic disorder; Phobias
Adult: Initially, 25 mg daily, gradually increased to 100-150 mg daily over 2 wk. Max: 250 mg daily.
Elderly: Initially, 10 mg daily.
Depression
Adult: Initially, 10 mg daily; may increase gradually to 30-150 mg daily if needed. Up to 250 mg daily or more may be required in more severe cases.
Elderly: Initially, 10 mg daily; may increase gradually over 10 days to 30-75 mg daily.
Max Dosage: 100-150 mg daily.
Child Dose
Obsessive-Compulsive Disorder
<10 years: Safety and efficacy not established
>10 years: 25 mg PO qDay initially
Gradually increase to maximum 3 mg/kg/day or 100 mg/day, whichever is less
May further increase to maximum 3 mg/kg/day or 200 mg/day, whichever is less; may give as single dose qHS once tolerated
Renal Dose
Administration
Should be taken with food.
Contra Indications
Hypersensitivity. Concomitant use of MAOIs; recovery phase following MI, heartblock or other arrhythmias; mania; childn.
Precautions
Cardiovascular insufficiency; narrow-angle glaucoma; urinary retention; history of epilepsy; renal or hepatic dysfunction; electroconvulsive therapy; hypotension; hyperthyroidism or concomitant treatment with thyroid preparations; suicidal tendencies; surgery; pregnancy and lactation; tasks requiring mental alertness; elderly; avoid abrupt withdrawal.
Lactation: distributed in breast milk, do not nurse (AAP states effect on nursing infants is unknown but may be of concern)
Pregnancy-Lactation
Pregnancy Category: C
Lactation: distributed in breast milk, do not nurse (AAP states effect on nursing infants is unknown but may be of concern)
Interactions
Barbiturates increase metabolism of tricyclic antidepressants; conversely cimetidine, guanethidine, haloperidol and phenothiazines block the tricyclic metabolism. CNS effects of alcohol enhanced.
Potentially Fatal: If clomipramine is to be substituted for MAOIs, at least 3 wk should elapse after discontinuing MAOIs. Risk of hypertension and arrhythmias if co-administered with adrenaline and noradrenaline.
Adverse Effects
Side effects of Clomipramine Hydrochloride :
>10%
Xerostomia (84%), Headache (50-55%), Constipation (47%), Ejaculation failure (42%), Fatigue (35-40%), Nausea (30-35%), Impotence (20-25%), Weight gain (18%)
1-10%
Weight loss (5%), Hepatotoxicity (1-3%)
Frequency Not Defined
Common, Dizziness, mainia, somnolence, tremor, Dyspepsia, Blurred vision, Urinary retention, Orgasm incapacity, libido change
Potentially Fatal: Death, rare (except in patients with preexisting significant heart block and patients on MAOI therapy). Induction of mania in individuals with underlying manic-depressive illness or worsening of psychoses in already psychotic individuals.
Mechanism of Action
Clomipramine is a potent inhibitor of serotonin re-uptake in the brain. Significant antagonism at cholinergic and ?1-receptors. Weak antagonism at dopamine receptors. It has also antidepressant, sedative and anticholinergic effects.
Note
Anafranil 25mg Tablets manufactured by Novartis Pharma AG. Its generic name is Clomipramine Hydrochloride. Anafranil is availble in United Arab Emirates.
Farmaco UAE drug index information on Anafranil Tablets is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.