Latanoprost 0.005% Eye prep

Indications

Latanoprost 0.005% Eye prep is used for: Open-angle glaucoma, Ocular HTN

Adult Dose

Adult: As 0.005% eye drop: Instill 1 drop in affected eye once daily in every evening.

Child Dose

Safety and efficacy not established

Renal Dose

Administration

Contra Indications

Hypersensitivity.

Precautions

Do not use within 5 min of thiomersal-containing preparations. Aphakia or pseudophakia with torn posterior lens cap or anterior chamber lenses; risk factors for cystoid macular oedema; brittle or severe asthma; history of intraocular inflammation; inflammatory, neovascular, angle-closure or congenital glaucoma; pregnancy, lactation. Remove contact lenses during use. Lactation: not known whether distributed into milk; use with caution

Pregnancy-Lactation

Pregnancy There are no adequate and well-controlled studies in pregnant women Only use during pregnancy if potential benefits justifies potential risks to the fetus Animal data Reproduction studies performed in rats and rabbits. In rabbits, an incidence of 4 of 16 dams had no viable fetuses at a dose that was ~80 times the maximum human dose, and the highest nonembryocidal dose in rabbits was ~15 times the maximum human dose Lactation Not known whether distributed in milk; use caution

Interactions

Paradoxical elevations in IOP w/ other prostaglandins, prostaglandin analogs or prostaglandin derivatives.

Adverse Effects

Side effects of Latanoprost 0.005% Eye prep : >10% Increase in brown pigmentation of the iris (15.5%), Blurred vision (5-15%), Burning and stinging (5-15%), Foreign body sensation (5-15%), Itching (5-15%), Punctate epithelial keratopathy (5-15%), Conjunctival hyperemia (5-15%) 1-10% Upper respiratory tract infection/cold/flu (4%), Dry eye (1-4%), Excessive tearing (1-4%), Eye pain (1-4%), Lid crusting (1-4%), Lid edema (1-4%), Lid erythema (1-4%), Lid discomfort/pain (1-4%), Photophobia (1-4%), Chest pain/angina pectoris (1-2%), Muscle/joint/back pain (1-2%), Rash/allergic skin reactions (1-2%) <1% Conjunctivitis, Diplopia, Discharge from the eye Frequency Not Defined Dizziness, Headache

Mechanism of Action

Latanoprost, a synthetic analogue of prostaglandin F2alpha, reduces the IOP by increasing the outflow of aqueous humour.